Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory ...

A new study led by Marco Fumasoni, principal investigator at Fundação GIMM, shows that evolution can substantially reduce ...

Reactive oxygen species (ROS) produced naturally during cellular metabolism often cause oxidative damage to cells. However, these molecules also play an important role in normal cellular signaling.

Scientists at Nagoya University in Japan studied what happens when macrophages—a type of immune cell—encounter dying cancer cells in tumors and discovered a mechanism that accelerates tumor growth.

T cells offer several advantages for solid tumor immunotherapy, including innate tumor recognition, human leukocyte ...

A newly developed synthetic cell matrix could provide a surface on which to culture and differentiate billions of delicate stem cells for medical uses. For decades, scientists have been exploring ...

Fighting cancer effectively often involves stopping cancer cells from multiplying, which requires understanding proteins that the cells rely on to survive. Protein profiling plays a critical role in ...

In this Review, we first briefly discuss ligand specificity of IR and IGF receptor. We then focus on recent structural and functional insights into the activation of IR family receptors and highlight ...

The growth plates contain special stem cells that continuously produce new cartilage cells, which are converted into bone tissue. In the case of growth disorders in children with a height ...

Researchers at Hospital for Special Surgery (HSS) have identified a specialized population of immune cells that play a ...

Impact of Circulating Tumor DNA and Copy-Number Alterations on Clinical Outcome in Relapsed/Refractory Germ Cell Tumors Treated With Salvage High-Dose Chemotherapy ASCO Guidelines provide ...