Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

Researchers have developed a revolutionary microscope that uses an incredibly powerful laser to make previously invisible ...

A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryo-EM microscope’s contrast, allowing biologists to ...

A continuous laser focused to a few microns, carrying 75 kilowatts of power, has been used to sharpen cryo-electron ...

Physicists have demonstrated a laser-based method that enables a cryogenic electron microscope to image small protein structures with greater detail than previously possible. The laser phase plate ...

A microscope born in post-war JapanThis time, I am introducing an old Olympus biological microscope, the UCE model 'Homare'.While the modern-day Olympus is known globally for its medical endoscopes, ...

The invention that first enabled researchers to see clear images of living cells was the phase-contrast microscope, which won its inventor, Frits Zernike, a Nobel Prize in 1932. Prior to Zernike's ...

Every year, thousands of patients with early-stage breast cancer undergo surgery that removes the tumor along with a rim of ...

Key points of this article In a 1983 letter, Dr. McArthur evaluated the Nippon Kogaku microscope as having excellent optical ...